Clinical Pharmacology Lead

Role : Clinical Pharmacology Lead

Location : Hybrid - must be able to commit to 2x days per week in Antwerp

The Role

We are seeking a highly Senior Clinical Pharmacology Lead to play a key, senior role in advancing a growing portfolio of innovative small-molecule therapies. This is a hands-on position with significant scientific ownership, where you will lead clinical pharmacology strategy from early translational development through proof of concept and beyond. You will act as a core individual contributor while progressively taking on broader leadership responsibilities as the pipeline and organization expand.

The Company

You will join a fast-growing, science-driven biotechnology company focused on developing novel therapies for serious diseases with high unmet medical need. The company combines deep biological insight with a strong commitment to translational science, quantitative decision-making, and close cross-functional collaboration. With an agile culture and ambitious development goals, this environment offers the opportunity to make a visible impact on programs and patients alike.

Key Responsibilities

• Serve as the Clinical Pharmacology lead for assigned clinical programs
• Develop and execute integrated clinical pharmacology plans aligned with overall clinical development strategy
• Design and support clinical pharmacology and PK / PD study protocols
• Perform and / or oversee population PK / PD, PBPK, and other quantitative analyses
• Apply model-informed drug development to support dose selection and compound progression
• Integrate nonclinical, translational, biomarker, and clinical data into coherent modelling strategies
• Interpret emerging PK / PD and biomarker data to inform development decisions
• Contribute to regulatory documents including INDs, IBs, protocols, and briefing packages
• Support regulatory interactions by providing data-driven dose and development justifications
• Collaborate closely with research, toxicology, clinical operations, biometrics, regulatory, and medical teams
• Manage and scientifically oversee CROs and external consultants
• Help build and mentor future clinical pharmacology team members as the function grows

Requirements