Topic description
The goal of this project is to design and synthesize peptides and peptidomimetics capable of inhibiting the aggregation of α-Synuclein and α-Synuclein binding to lipids. Molecular simulations will be performed to prove the mode of action of the best-performing inhibitors and to design improved inhibitors.
In particular, the DC enrolled in this position, will synthesize peptide mimics to modulate the pathological α-Synuclein protein aggregation as well as α-Synuclein/lipids interaction. He/She will be involved in the synthesis of unnatural scaffolds, i.e. non natural amino acids and of peptide mimics, designed according to the results of the structural biology results of the consortium. He/She will also perform conformational studies using NMR techniques, and will be involved in some biophysical and biochemical evaluations of the activity and the interaction of the prepared compounds with α-Synuclein or with lipids.
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
The goal of this project is to design and synthesize peptides and peptidomimetics capable of inhibiting the aggregation of α-Synuclein and α-Synuclein binding to lipids. Molecular simulations will be performed to prove the mode of action of the best-performing inhibitors and to design improved inhibitors.
In particular, the DC enrolled in this position, will synthesize peptide mimics to modulate the pathological α-Synuclein protein aggregation as well as α-Synuclein/lipids interaction. He/She will be involved in the synthesis of unnatural scaffolds, i.e. non natural amino acids and of peptide mimics, designed according to the results of the structural biology results of the consortium. He/She will also perform conformational studies using NMR techniques, and will be involved in some biophysical and biochemical evaluations of the activity and the interaction of the prepared compounds with α-Synuclein or with lipids.
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Début de la thèse : 01/09/
WEB :
Funding category
Funding further details
Europe - MSCA (Marie Sklodowska-Curie Action)