Instrumental developments of ultra-low field MRI forInstrumental developments of ultra-low field MRI for the in vivo detection of inflammation in rodents
Topic description
The development of Personalized Medicine involves the implementation of new diagnostic approaches which goal is identification of molecular mechanisms specific to emergence of pathologies.
In this context, inflammatory processes and certain cancers involve the activity of enzymes, such as proteases, which constitute a target of choice for early diagnosis by imaging techniques such as Magnetic Resonance Imaging (MRI).
Our laboratory has developed an unique MRI approach at 0.19 Tesla and using Dynamic Polarization. It made it possible to visualize for the first time and in vivo, the location of the activity of proteases specific to a given biological process in mice.
With the idea of extending this method to larger animals and to humans, an experimental prototype of MRI with variable fields ranging from the Earth’s field to µT, has been assembled.
A Dynamic Polarization specific channel was included, and some coils were built. Initial tests have been carried out to show feasibility of the concept.
The aim of the project is to pursue the development of new very low field ( µT) MRI instruments using Dynamic Polarization, and to evaluate new radical molecules to test their ability to produce contrast in MRI in the context of inflammatory diseases in rodents.
Program of the thesis project :
- Getting started with existing instruments at UMR : MRI at 0.19T, MRI at µT
- Developments of instruments at µT
- Validation of dynamic polarization in vitro in the presence of dedicated chemical probes
- In vivo measurement of enzymatic activity by MRI enhanced by dynamic polarization
Candidate profile : The student must have a strong background in NMR and / or electronics, as well as in programming languages (Matlab, Python).
Additional Information : The candidate will integrate a stimulating environment and will be integrated to the "low field" team of the CRMSB (Centre de Résonance Magnetics of Biological Systems, UMR CNRS / University of Bordeaux, in Bordeaux.
The thesis is part of a MITI (CNRS interdisciplinary programme) project called "BISRADIRM" and involving the Institute of Radical Chemistry of the University of Aix-Marseille (team CRAB UMR and the CRMSB.
It will start in October .
Starting date
11-13
Funding category
Public / private mixed funding
Funding further details
- Projet MITI nommé "BISRADIM" ;
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